Meet Tex Murphy, a P.I. working the mean streets of post-apocalyptic San Francisco. When a beautiful woman enters Tex's office and hires him to investigate her father's apparent suicide, she sends Tex straight into the middle of a frightening mix of science, murder, and world domination.

Soon, Tex finds himself the newest addition to an ever-growing hit list of those who stand in the way of a plot nearly 50 years in the making, and must think of a way to stop the powerful people behind it from carrying out their plans—before he, and the rest of the world, is unable to think at all.